Janice Mayne – NorthOmics

Research Associate

jmayn2[AT]uottawa.ca

Janice Mayne completed a B.Sc. (Hon) and PhD in Biochemistry from Memorial University of Newfoundland and carried out postdoctoral studies at the Ottawa Hospital Research Institute. She is currently a Research Associate with Professor Daniel Figeys at the Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology at the University of Ottawa. Her studies focus on the role of endoproteolyses in health and disease using a combination of biochemistry, cell biology, and proteomic techniques.

Publications

Comerlato CB, Zhang X, Walker K, Mayne J, Figeys D and Brandelli A. The Influence of Protein Secretomes of Enterococcus durans on ex vivo Human Gut Microbiome. (2023) Probiotics Antimicrob Proteins. Pubmed Probiotics Antimicrob Proteins

Morales SV, Mahmood A, Pollard J, Mayne J, Figeys D and Wiseman PW. The LDL receptor is regulated by membrane cholesterol as revealed by fluorescence fluctuation analysis. (2023) Biophys J. Pubmed Biophys J

Li L, Wang T, Ning Z, Zhang X, Butcher J, Serrana JM, Simopoulos CMA, Mayne J, Stintzi A, Mack DR, Liu YY and Figeys D. Revealing proteome-level functional redundancy in the human gut microbiome using ultra-deep metaproteomics. (2023) Nat Commun. 14, 3428 Pubmed Nat Commun PMC Article

Cheng K, Ning Z, Li L, Zhang X, Serrana JM, Mayne J and Figeys D. MetaLab-MAG: A Metaproteomic Data Analysis Platform for Genome-Level Characterization of Microbiomes from the Metagenome-Assembled Genomes Database. (2023) J Proteome Res. 22, 387-398 Pubmed J Proteome Res PMC Article

Liu Y, Bilen M, McNicoll MM, Harris RA, Fong BC, Iqbal MA, Paul S, Mayne J, Walker K, Wang J, Figeys D and Slack RS. Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer's disease. (2023) Cell Death Dis. 14, 138 Pubmed Cell Death Dis PMC Article

Creskey M, Li L, Ning Z, Fekete EE, Mayne J, Walker K, Ampaw A, Ben R, Zhang X and Figeys D. An economic and robust TMT labeling approach for high throughput proteomic and metaproteomic analysis. (2022) Proteomics. e2200116 Pubmed Proteomics

Duan H, Cheng K, Ning Z, Li L, Mayne J, Sun Z and Figeys D. Assessing the Dark Field of Metaproteome. (2022) Anal Chem. 94, 15648-15654 Pubmed Anal Chem PMC Article

Sun Z, Wang W, Li L, Zhang X, Ning Z, Mayne J, Walker K, Stintzi A and Figeys D. Comprehensive Assessment of Functional Effects of Commonly Used Sugar Substitute Sweeteners on Human Gut Microbiome. (2022) Microbiol Spectr. 10, e0041222 Pubmed Microbiol Spectr PMC Article

Mayne J, Zhang X, Butcher J, Walker K, Ning Z, Wójcik E, Dastych J, Stintzi A and Figeys D. Examining the Effects of an Anti-Salmonella Bacteriophage Preparation, BAFASAL, on Ex-Vivo Human Gut Microbiome Composition and Function Using a Multi-Omics Approach. (2021) Viruses. 13, Pubmed Viruses PMC Article

Zhang X, Cheng K, Ning Z, Mayne J, Walker K, Chi H, Farnsworth CL, Lee K and Figeys D. Exploring the Microbiome-Wide Lysine Acetylation, Succinylation, and Propionylation in Human Gut Microbiota. (2021) Anal Chem. 93, 6594-6598 Pubmed Anal Chem

D'Aoust PM, Graber TE, Mercier E, Montpetit D, Alexandrov I, Neault N, Baig AT, Mayne J, Zhang X, Alain T, Servos MR, Srikanthan N, MacKenzie M, Figeys D, Manuel D, Jüni P, MacKenzie AE and Delatolla R. Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 h before COVID-19 clinical tests and 96 h before hospitalizations. (2021) Sci Total Environ. 770, 145319 Pubmed Sci Total Environ PMC Article

D'Aoust PM, Mercier E, Montpetit D, Jia JJ, Alexandrov I, Neault N, Baig AT, Mayne J, Zhang X, Alain T, Langlois MA, Servos MR, MacKenzie M, Figeys D, MacKenzie AE, Graber TE and Delatolla R. Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalence. (2021) Water Res. 188, 116560 Pubmed Water Res PMC Article

Smyth P, Zhang X, Ning Z, Mayne J, Moore JI, Walker K, Lavallée-Adam M and Figeys D. Studying the Temporal Dynamics of the Gut Microbiota Using Metabolic Stable Isotope Labeling and Metaproteomics. (2020) Anal Chem. 92, 15711-15718 Pubmed Anal Chem

Li L, Chang L, Zhang X, Ning Z, Mayne J, Ye Y, Stintzi A, Liu J and Figeys D. Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes. (2020) Gut Microbes. 11, 1348-1361 Pubmed Gut Microbes PMC Article

Zhang X, Ning Z, Mayne J, Yang Y, Deeke SA, Walker K, Farnsworth CL, Stokes MP, Couture JF, Mack D, Stintzi A and Figeys D. Widespread protein lysine acetylation in gut microbiome and its alterations in patients with Crohn's disease. (2020) Nat Commun. 11, 4120 Pubmed Nat Commun PMC Article

Duval S, Abu-Thuraia A, Elkholi IE, Chen R, Seebun D, Mayne J, Côté JF, Figeys D and Seidah NG. Shedding of cancer susceptibility candidate 4 by the convertases PC7/furin unravels a novel secretory protein implicated in cancer progression. (2020) Cell Death Dis. 11, 665 Pubmed Cell Death Dis PMC Article

Hao Z, Li L, Ning Z, Zhang X, Mayne J, Cheng K, Walker K, Liu H and Figeys D. Metaproteomics Reveals Growth Phase-Dependent Responses of an Gut Microbiota to Metformin. (2020) J Am Soc Mass Spectrom. 31, 1448-1458 Pubmed J Am Soc Mass Spectrom

Cheng K, Ning Z, Zhang X, Li L, Liao B, Mayne J and Figeys D. MetaLab 2.0 Enables Accurate Post-Translational Modifications Profiling in Metaproteomics. (2020) J Am Soc Mass Spectrom. 31, 1473-1482 Pubmed J Am Soc Mass Spectrom

Wang J, Zhang X, Li L, Ning Z, Mayne J, Schmitt-Ulms C, Walker K, Cheng K and Figeys D. Differential Lysis Approach Enables Selective Extraction of Taxon-Specific Proteins for Gut Metaproteomics. (2020) Anal Chem. 92, 5379-5386 Pubmed Anal Chem

Li L, Ning Z, Zhang X, Mayne J, Cheng K, Stintzi A and Figeys D. RapidAIM: a culture- and metaproteomics-based Rapid Assay of Individual Microbiome responses to drugs. (2020) Microbiome. 8, 33 Pubmed Microbiome PMC Article

Li H, Li L, Cheng K, Ning Z, Mayne J, Zhang X, Walker K, Chen R, Twine S, Li J and Figeys D. Chemoenzymatic Method for Glycoproteomic N-Glycan Type Quantitation. (2020) Anal Chem. 92, 1618-1627 Pubmed Anal Chem

Adler P, Mayne J, Walker K, Ning Z and Figeys D. Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model. (2019) J Proteome Res. 18, 3383-3393 Pubmed J Proteome Res

Li L, Abou-Samra E, Ning Z, Zhang X, Mayne J, Wang J, Cheng K, Walker K, Stintzi A and Figeys D. An in vitro model maintaining taxon-specific functional activities of the gut microbiome. (2019) Nat Commun. 10, 4146 Pubmed Nat Commun PMC Article

Peters DL, Wang W, Zhang X, Ning Z, Mayne J and Figeys D. Metaproteomic and Metabolomic Approaches for Characterizing the Gut Microbiome. (2019) Proteomics. 19, e1800363 Pubmed Proteomics

Liao B, Ning Z, Cheng K, Zhang X, Li L, Mayne J and Figeys D. iMetaLab 1.0: a web platform for metaproteomics data analysis. (2018) Bioinformatics. 34, 3954-3956 Pubmed Bioinformatics

Mayne J, Ooi TC, Tepliakova L, Seebun D, Walker K, Mohottalage D, Ning Z, Abujrad H, Mbikay M, Wassef H, Chrétien M and Figeys D. Associations Between Soluble LDLR and Lipoproteins in a White Cohort and the Effect of PCSK9 Loss-of-Function. (2018) J Clin Endocrinol Metab. 103, 3486-3495 Pubmed J Clin Endocrinol Metab

Zhang X, Deeke SA, Ning Z, Starr AE, Butcher J, Li J, Mayne J, Cheng K, Liao B, Li L, Singleton R, Mack D, Stintzi A and Figeys D. Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease. (2018) Nat Commun. 9, 2873 Pubmed Nat Commun PMC Article

Deeke SA, Starr AE, Ning Z, Ahmadi S, Zhang X, Mayne J, Chiang CK, Singleton R, Benchimol EI, Mack DR, Stintzi A and Figeys D. Mucosal-luminal interface proteomics reveals biomarkers of pediatric inflammatory bowel disease-associated colitis. (2018) Am J Gastroenterol. 113, 713-724 Pubmed Am J Gastroenterol

Zhang X, Li L, Mayne J, Ning Z, Stintzi A and Figeys D. Assessing the impact of protein extraction methods for human gut metaproteomics. (2018) J Proteomics. 180, 120-127 Pubmed J Proteomics

Li L, Zhang X, Ning Z, Mayne J, Moore JI, Butcher J, Chiang CK, Mack D, Stintzi A and Figeys D. Evaluating in Vitro Culture Medium of Gut Microbiome with Orthogonal Experimental Design and a Metaproteomics Approach. (2018) J Proteome Res. 17, 154-163 Pubmed J Proteome Res

Cheng K, Ning Z, Zhang X, Li L, Liao B, Mayne J, Stintzi A and Figeys D. MetaLab: an automated pipeline for metaproteomic data analysis. (2017) Microbiome. 5, 157 Pubmed Microbiome PMC Article

Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D and Palczewski K. Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. (2017) J Biol Chem. 292, 19826-19839 Pubmed J Biol Chem PMC Article

Zhang X, Chen W, Ning Z, Mayne J, Mack D, Stintzi A, Tian R and Figeys D. Deep Metaproteomics Approach for the Study of Human Microbiomes. (2017) Anal Chem. 89, 9407-9415 Pubmed Anal Chem

Zhang X, Ning Z, Mayne J, Deeke SA, Li J, Starr AE, Chen R, Singleton R, Butcher J, Mack DR, Stintzi A and Figeys D. In Vitro Metabolic Labeling of Intestinal Microbiota for Quantitative Metaproteomics. (2016) Anal Chem. 88, 6120-5 Pubmed Anal Chem

Zhang X, Ning Z, Mayne J, Moore JI, Li J, Butcher J, Deeke SA, Chen R, Chiang CK, Wen M, Mack D, Stintzi A and Figeys D. MetaPro-IQ: a universal metaproteomic approach to studying human and mouse gut microbiota. (2016) Microbiome. 4, 31 Pubmed Microbiome PMC Article

Ning Z, Star AT, Mierzwa A, Lanouette S, Mayne J, Couture JF and Figeys D. A charge-suppressing strategy for probing protein methylation. (2016) Chem Commun (Camb). 52, 5474-7 Pubmed Chem Commun (Camb)

Ning Z, Zhang X, Mayne J and Figeys D. Peptide-Centric Approaches Provide an Alternative Perspective To Re-Examine Quantitative Proteomic Data. (2016) Anal Chem. 88, 1973-8 Pubmed Anal Chem

Mayne J, Ning Z, Zhang X, Starr AE, Chen R, Deeke S, Chiang CK, Xu B, Wen M, Cheng K, Seebun D, Star A, Moore JI and Figeys D. Bottom-Up Proteomics (2013-2015): Keeping up in the Era of Systems Biology. (2016) Anal Chem. 88, 95-121 Pubmed Anal Chem

Starr AE, Lemieux V, Noad J, Moore JI, Dewpura T, Raymond A, Chrétien M, Figeys D and Mayne J. β-Estradiol results in a proprotein convertase subtilisin/kexin type 9-dependent increase in low-density lipoprotein receptor levels in human hepatic HuH7 cells. (2015) FEBS J. 282, 2682-96 Pubmed FEBS J PMC Article

Chiang CK, Mehta N, Patel A, Zhang P, Ning Z, Mayne J, Sun WY, Cheng HY and Figeys D. The proteomic landscape of the suprachiasmatic nucleus clock reveals large-scale coordination of key biological processes. (2014) PLoS Genet. 10, e1004695 Pubmed PLoS Genet PMC Article

Mayne J, Starr AE, Ning Z, Chen R, Chiang CK and Figeys D. Fine tuning of proteomic technologies to improve biological findings: advancements in 2011-2013. (2014) Anal Chem. 86, 176-95 Pubmed Anal Chem

Denis N, Palmer-Smith H, Elisma F, Busuttil A, Wright TG, Bou Khalil M, Prat A, Seidah NG, Chrétien M, Mayne J and Figeys D. Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells. (2011) J Proteome Res. 10, 2011-26 Pubmed J Proteome Res

Li L, Ryan J, Ning Z, Zhang X, Mayne J, Lavallée-Adam M, Stintzi A and Figeys D. A functional ecological network based on metaproteomics responses of individual gut microbiomes to resistant starches. (2020) Comput Struct Biotechnol J. 18, 3833-3842 Pubmed Comput Struct Biotechnol J PMC Article

Adler P, Chiang CK, Mayne J, Ning Z, Zhang X, Xu B, Cheng HM and Figeys D. Aging Disrupts the Circadian Patterns of Protein Expression in the Murine Hippocampus. (2019) Front Aging Neurosci. 11, 368 Pubmed Front Aging Neurosci PMC Article

Zhang X, Walker K, Mayne J, Li L, Ning Z, Stintzi A and Figeys D. Evaluating live microbiota biobanking using an microbiome assay and metaproteomics. (2022) Gut Microbes. 14, 2035658 Pubmed Gut Microbes PMC Article

Chiang CK, Xu B, Mehta N, Mayne J, Sun WY, Cheng K, Ning Z, Dong J, Zou H, Cheng HM and Figeys D. Phosphoproteome Profiling Reveals Circadian Clock Regulation of Posttranslational Modifications in the Murine Hippocampus. (2017) Front Neurol. 8, 110 Pubmed Front Neurol PMC Article