NorthOmics

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Leyuan Li

Research Associate

lli8[AT]uottawa.ca

RESEARCH

JUN/2016 – PRESENT

Postdoctoral fellow and RA, Dr. Daniel Figeys’ Lab, University of Ottawa, Canada

Keywords: gut microbiome, metaproteomics, in vitro system

SEP/2010 –JAN/2016

PhD studies, responsible designer of the waste bioconversion system of the Lunar Palace 1 (phase I), China

Keywords: microbial community, fermentation, bioreactor, artificial ecosystem

SEP/2012-DEC/2012

Visiting scholar, Controlled Environment Systems Research Facility, University of Guelph, Canada

Keyword: controlled-ecological system

 

EDUCATION & TRAINING

SEP/2017 – SEP/2019

Trainee of TECHNOMISE

TECHNOlogies for MIcrobiome Science and Engineering, a NSERC CREATE Training Program, Ottawa, Canada

SEP/2010 –JAN/2016

Ph.D. in Biomedical Engineering

School of Biological Science and Medical Engineering, Beihang University, Beijing, China

SEP/2006 – JUN/2010

B.Eng. in Biological Engineering

School of Biological Science and Medical Engineering, Beihang University, Beijing, China

 

Publications in NorthOmics

Li L, Chang L, Zhang X, Ning Z, Mayne J, Ye Y, Stintzi A, Liu J and Figeys D. Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes. (2020) Gut Microbes. 11, 1348-1361 Pubmed Gut Microbes PMC Article
Li L and Figeys D. Proteomics and Metaproteomics Add Functional, Taxonomic and Biomass Dimensions to Modeling the Ecosystem at the Mucosal-luminal Interface. (2020) Mol Cell Proteomics. 19, 1409-1417 Pubmed Mol Cell Proteomics PMC Article
Simopoulos CMA, Ning Z, Zhang X, Li L, Walker K, Lavallée-Adam M and Figeys D. pepFunk: a tool for peptide-centric functional analysis of metaproteomic human gut microbiome studies. (2020) Bioinformatics. 36, 4171-4179 Pubmed Bioinformatics
Hao Z, Li L, Ning Z, Zhang X, Mayne J, Cheng K, Walker K, Liu H and Figeys D. Metaproteomics Reveals Growth Phase-Dependent Responses of an Gut Microbiota to Metformin. (2020) J Am Soc Mass Spectrom. 31, 1448-1458 Pubmed J Am Soc Mass Spectrom
Cheng K, Ning Z, Zhang X, Li L, Liao B, Mayne J and Figeys D. MetaLab 2.0 Enables Accurate Post-Translational Modifications Profiling in Metaproteomics. (2020) J Am Soc Mass Spectrom. 31, 1473-1482 Pubmed J Am Soc Mass Spectrom
Wang J, Zhang X, Li L, Ning Z, Mayne J, Schmitt-Ulms C, Walker K, Cheng K and Figeys D. Differential Lysis Approach Enables Selective Extraction of Taxon-Specific Proteins for Gut Metaproteomics. (2020) Anal Chem. 92, 5379-5386 Pubmed Anal Chem
Li L, Ning Z, Zhang X, Mayne J, Cheng K, Stintzi A and Figeys D. RapidAIM: a culture- and metaproteomics-based Rapid Assay of Individual Microbiome responses to drugs. (2020) Microbiome. 8, 33 Pubmed Microbiome PMC Article
Li H, Li L, Cheng K, Ning Z, Mayne J, Zhang X, Walker K, Chen R, Twine S, Li J and Figeys D. Chemoenzymatic Method for Glycoproteomic N-Glycan Type Quantitation. (2020) Anal Chem. 92, 1618-1627 Pubmed Anal Chem
Zhang X, Li L, Butcher J, Stintzi A and Figeys D. Advancing functional and translational microbiome research using meta-omics approaches. (2019) Microbiome. 7, 154 Pubmed Microbiome PMC Article
Li L, Abou-Samra E, Ning Z, Zhang X, Mayne J, Wang J, Cheng K, Walker K, Stintzi A and Figeys D. An in vitro model maintaining taxon-specific functional activities of the gut microbiome. (2019) Nat Commun. 10, 4146 Pubmed Nat Commun PMC Article
Liao B, Ning Z, Cheng K, Zhang X, Li L, Mayne J and Figeys D. iMetaLab 1.0: a web platform for metaproteomics data analysis. (2018) Bioinformatics. 34, 3954-3956 Pubmed Bioinformatics
Zhang X, Deeke SA, Ning Z, Starr AE, Butcher J, Li J, Mayne J, Cheng K, Liao B, Li L, Singleton R, Mack D, Stintzi A and Figeys D. Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease. (2018) Nat Commun. 9, 2873 Pubmed Nat Commun PMC Article
Zhang X, Li L, Mayne J, Ning Z, Stintzi A and Figeys D. Assessing the impact of protein extraction methods for human gut metaproteomics. (2018) J Proteomics. 180, 120-127 Pubmed J Proteomics
Starr AE, Deeke SA, Li L, Zhang X, Daoud R, Ryan J, Ning Z, Cheng K, Nguyen LVH, Abou-Samra E, Lavallée-Adam M and Figeys D. Proteomic and Metaproteomic Approaches to Understand Host-Microbe Interactions. (2018) Anal Chem. 90, 86-109 Pubmed Anal Chem
Li L, Zhang X, Ning Z, Mayne J, Moore JI, Butcher J, Chiang CK, Mack D, Stintzi A and Figeys D. Evaluating in Vitro Culture Medium of Gut Microbiome with Orthogonal Experimental Design and a Metaproteomics Approach. (2018) J Proteome Res. 17, 154-163 Pubmed J Proteome Res
Cheng K, Ning Z, Zhang X, Li L, Liao B, Mayne J, Stintzi A and Figeys D. MetaLab: an automated pipeline for metaproteomic data analysis. (2017) Microbiome. 5, 157 Pubmed Microbiome PMC Article
Zhang X, Walker K, Mayne J, Li L, Ning Z, Stintzi A and Figeys D. Evaluating live microbiota biobanking using an microbiome assay and metaproteomics. Gut Microbes. 14, 2035658 Pubmed Gut Microbes PMC Article
Li L, Ryan J, Ning Z, Zhang X, Mayne J, Lavallée-Adam M, Stintzi A and Figeys D. A functional ecological network based on metaproteomics responses of individual gut microbiomes to resistant starches. (2020) Comput Struct Biotechnol J. 18, 3833-3842 Pubmed Comput Struct Biotechnol J PMC Article

Previous Publications

Hao Z, Li L (co-first), Fu Y et al. The influence of bioregenerative life-support system (BLSS) dietary structure and lifestyle on the gut microbiota: A 105-day ground-based space simulation in Lunar Palace 1: The influence of BLSS on gut microbiota. Environ Microbiol. 2018 Oct;20(10):3643-3656.

Fu Y, Li L (co-first), Xie B, et al. How to establish a bioregenerative life support system for long-term crewed missions to the moon or mars. Astrobiology, 2016, 16(12): 925-936.

Li L, Su Q, Xie B, et al. Gut microbes in correlation with mood: case study in a closed experimental human life support system. Neurogastroenterology & Motility, 2016, 28(8): 1233-1240.

Li L, Xie B, Dong C, et al. Can closed artificial ecosystem have an impact on insect microbial community? A case study of yellow mealworm (Tenebrio molitor L.). Ecological Engineering, 2016, 86: 183-189.

Li L, Stasiak M, Li L, et al. Rearing Tenebrio molitor in BLSS: dietary fiber affects larval growth, development, and respiration characteristics. Acta Astronautica, 2016, 118: 130-136.

Li L, Zhao Z, Liu H. Feasibility of feeding yellow mealworm (Tenebrio molitor L.) in bioregenerative life support systems as a source of animal protein for humans. Acta Astronautica, 2013, 92(1): 103-109.

Li L, Xie B, Dong C, et al. Rearing Tenebrio molitor L. (Coleptera: Tenebrionidae) in the “Lunar Palace 1” during a 105-day multi-crew closed integrative BLSS experiment. Life Sciences in Space Research, 2015, 7: 9-14.

Li L, Xie B, Fu W, et al. Allelopathic potential and chemical components of aqueous extract from soil-like substrate. Advanced Materials Research, 2012, 455-456: 490-495.